A single dose of erythropoietin in ST-elevation myocardial infarction
Why the study?
Does a single high dose of erythropoietin improve left ventricular ejection fraction in patients with a successful PCI for a first STEMI?
Population
529 patients with a successful primary coronary intervention for a first ST-elevation myocardial infarction
Comparison
Single bolus of 60,000 IU i.v. epoetin alfa… vs Standard medical care alone
Design
RCT, randomized
Follow-up
mean 6.5 (± 2.0) weeks
Authors
Discussion
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Member takes
Implication
No role for erythropoietin after STEMI PCI to preserve LVEF; confirms neutral effect in this RCT.
Structured PICO
Does a single high dose of erythropoietin improve left ventricular ejection fraction in patients with a successful PCI for a first STEMI?
P
Population
529 patients with a successful primary coronary intervention (PCI) for a first ST-elevation myocardial infarction (STEMI)
I
Intervention
Single bolus of 60,000 IU i.v. epoetin alfa within 3 h after PCI, in combination with standard medical care
C
Comparator
Standard medical care alone
O
Outcome
Left ventricular ejection fraction (LVEF) after 6 weeks, assessed by planar radionuclide ventriculographysurrogate
A single high dose of erythropoietin administered after primary PCI for STEMI does not improve left ventricular ejection fraction at 6 weeks.
Cite This Study
Voors et al. (2010) studied this question.