Complete remission of recurrent uterine angiosarcoma following long‑term systemic chemotherapy with paclitaxel and carboplatin: A case report

Figures

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  Figure 1.. Magnetic resonance imaging. (A) T2-weighted image. A 27×20 cm mass (white arrowhead) with heterogeneous high and low signal areas in the uterus. (B) Diffusion-weighted image. The solid part of the tumor showed a high signal (white arrowhead). (C) Apparent diffusion coefficient map. The solid part of the tumor showed a low signal (white arrowhead). (D) Sagittal section. There was no invasion into the cervix or malignant tumor of cervical origin (white arrowhead).

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  Figure 2.. Radiological findings. (A) Computed tomography scan. A heterogeneous, septate, mixed-density mass was seen in the transverse section. (B) Positron emission tomography-computed tomography. Hypermetabolism was seen in the area where the presence of a malignant tumor was suggested by magnetic resonance imaging (white arrowhead).

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  Figure 3.. Macroscopic image. (A) Intraoperative findings showed a smooth, enlarged uterus with numerous dilated blood vessels, and strong adhesion (white arrowhead) between the uterus and sigmoid colon. (B) A spongy, hemorrhagic tumor with necrotic tissue.

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  Figure 4.. Pathological findings. (A) Hematoxylin and eosin stain. The atypical cells with enlarged nuclei and distinct nucleoli formed a reticular structure like a vascular cavity and exhibited signs of proliferation. Magnification, ×100. (B) CD31 staining showed a strong positive signal in the malignant cells. Magnification, ×100. (C) CD34 staining showed a partially positive signal in the malignant cells. Magnification, ×200.

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  Figure 5.. Computed tomography scan performed 1 month after surgery. The largest of the three new solid tumors that had recurred in the abdominal cavity (maximum diameter 7 cm) (white arrowhead).