Why the study?
Does n-3 polyunsaturated fatty acids reduce circulating levels of microparticles in patients with a previous myocardial infarction?
Population
46 patients with a previous myocardial infarction
Comparison
n-3 polyunsaturated fatty acids 5.2 g daily for… vs Olive oil placebo for 12 weeks
Design
RCT
Follow-up
12 weeks
Authors
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n-3 fatty acids lower procoagulant microparticles post-MI; extends RCT evidence for antithrombotic effects in secondary prevention.
Does n-3 polyunsaturated fatty acids reduce circulating levels of microparticles in patients with a previous myocardial infarction?
High-dose n-3 fatty acids reduce platelet- and monocyte-derived microparticles and procoagulant activity in post-MI patients, suggesting a potential anti-thrombotic mechanism.
Turco et al. (2008) studied this question.
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