January 1, 1999AJP Regulatory Integrative and Comparative Physiology

Preoptic recess noradrenergic receptors control modification of baroreflex sensitivity by hypertonicity

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Population

Preclinical model (species not specified in abstract)

Comparison

Local administration of hypertonic artificial… vs Control conditions (implied)

Design

Preclinical

Authors

SBSteven L. BealerUniversity of Utah

Discussion

Member takes

Implication

Identifies AV3V alpha2-adrenergic modulation of baroreflex bradycardia in animals; leaves open translation to human cardiovascular disease.

Structured PICO

Population

Preclinical model (species not specified in abstract)

Intervention

Local administration of hypertonic artificial cerebrospinal fluid (aCSF) in the anteroventral portion of the third cerebral ventricle (AV3V), with or without alpha-adrenoreceptor antagonists (phentolamine, yohimbine, prazosin)

Comparator

Control conditions (implied)

Outcome

Baroreflex-induced changes in heart rate and renal sympathetic nerve activity (RSNA)surrogate

Acute, local hypertonic stimulation in the AV3V region selectively enhances baroreflex-induced bradycardia by stimulation of alpha2-adrenergic receptors during acute pressor responses.

Cite This Study

Steven L. Bealer (1999) studied this question.

synapsesocial.com/papers/6a83b9f06eaad3b729ee7eae https://doi.org/10.1152/ajpregu.1999.276.1.r44

View Full Paper

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Implication

Identifies AV3V alpha2-adrenergic modulation of baroreflex bradycardia in animals; leaves open translation to human cardiovascular disease.

Preoptic recess noradrenergic receptors control modification of baroreflex sensitivity by hypertonicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preoptic recess noradrenergic receptors control modification of baroreflex sensitivity by hypertonicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider