Experimental study demonstrates that arterial wall tone modulates carotid sinus baroreceptors, suggesting reduced stretch resistance underlies essential hypertension.
Experiments show that the state of tone and contraction and thus the resistance to stretch of the arterial wall where the pressoceptors of the carotid sinus are located, are the primary factors affecting these receptors which regulate and moderate reflexly the systemic arterial pressure. Decrease of resistance to stretch of the arterial wall, where the receptors of the sinoaortic nerves which moderate reflexly the general arterial pressure are situated, could be the primary mechanism of essential hypertension.
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Heymans et al. (1951) studied this question.
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