Why the study?
To evaluate the effects of hypertension and exercise training on the interplay between the renin-angiotensin system, autonomic control, and heart remodeling during hypertension development in spontaneously hypertensive rats.
Does exercise training improve autonomic control and heart remodeling in spontaneously hypertensive rats?
Does exercise training improve autonomic control and heart remodeling in spontaneously hypertensive rats?
Exercise training attenuates cardiac remodeling and autonomic dysfunction during the transition to hypertension in spontaneously hypertensive rats, partly by modulating the renin-angiotensin system.
Supports autonomic and remodeling benefits in hypertensive rat models; leaves open translation to human hypertension prevention.
BACKGROUND: The effects of hypertension and exercise training (T) on the sequential interplay between renin-angiotensin system (RAS), autonomic control and heart remodeling during the development of hypertension in spontaneously hypertensive rats (SHR), was evaluated. METHODS AND RESULTS: R protein content, myocytes's hypertrophy, collagen deposition and increased pressure variability were observed in 12-week-old sedentary SHR. In addition to attenuating all these effects, T activated Mas receptor expression augmented parasympathetic modulation of the heart, and delayed the onset and reduced the magnitude, but did not block the development of genetic hypertension. CONCLUSIONS: R pathway in driving cardiac remodeling and autonomic modulation during the transition from the pre- to hypertensive phase.
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Costa et al. (2020) studied this question.
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