What question did this study set out to answer?

To determine whether growth hormone deficiency of childhood onset impairs adult bone mineral content in men, including those who previously received hormone replacement.

January 1, 1992The Journal of Clinical Endocrinology & Metabolism

Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset.

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To determine whether growth hormone deficiency of childhood onset impairs adult bone mineral content in men, including those who previously received hormone replacement.
Assessed bone mineral content in 30 adult men with childhood-onset growth hormone deficiency (8 isolated, 22 multiple pituitary deficiencies; 28 previously treated with growth hormone) and 30 controls matched for age (within 4 years) and height (within 10 cm).
Measured forearm bone mineral content using single photon absorptiometry at proximal and distal sites, and lumbar spine (L2–L4) content and density using dual photon absorptiometry, with serial measurements in 19 patients across 6 to 28 months.
Patients had significantly lower bone mineral content than controls at the forearm (proximal PBMC-2: 35.7 ± 1.0 vs. 50.0 ± 1.6; distal DBMC-2: 36.9 ± 1.2 vs. 52.8 ± 1.9; P < 0.0001) and lumbar spine (LBMC: 34.00 ± 1.08 vs. 42.02 ± 1.27 g; LBMD: 0.886 ± 0.016 vs. 0.976 ± 0.018 g/cm2; P < 0.005).
Osteopenia was present in both isolated and multiple pituitary deficiency subgroups compared to controls, with a larger relative deficit at the forearm (20% to 30% reduction) than at the lumbar spine (9% to 19% reduction).
Serial measurements over 6 to 28 months in 19 patients showed stable bone mineral content without further progressive bone loss.

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Implication

Matched case-control study reveals reduced bone mineral density in men with childhood-onset growth hormone deficiency, indicating lasting skeletal deficits despite prior hormone therapy.

Cite This Study

Kaufman et al. (1992) studied this question.

synapsesocial.com/papers/6a83bf8f67f654fd873c1c6e https://doi.org/10.1210/jcem.74.1.1727808

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Implication

Matched case-control study reveals reduced bone mineral density in men with childhood-onset growth hormone deficiency, indicating lasting skeletal deficits despite prior hormone therapy.

Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset.

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Discussion

Implication

Cite This Study

Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset.

Key Points

Discussion

Implication

Cite This Study

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