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January 1, 1990Thrombosis and Haemostasis

Thrombosis and Pregnancy in Congenital Deficiencies in AT III, Protein C or Protein S: Study of 78 Women

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Population

78 women with congenital deficiency in antithrombin III (AT III), Protein C (PC), or Protein S (PS)

Design

Cohort

Authors

JCJ. ConardCase Western Reserve UniversityPDPatrick Van DredenInsermTLThomas LecompteUniversity of Namur

Discussion

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Implication

May warrant vigilance for early VTE in deficient women during pregnancy; leaves open optimal prophylaxis strategies.

Key Points

  • Assess the risk and clinical presentation of venous thromboembolism in pregnant women with congenital deficiencies in antithrombin III, protein C, or protein S.
  • Evaluated a cohort of 78 women with diagnosed congenital deficiencies in antithrombin III, protein C, or protein S.
  • Documented occurrences of venous thromboembolism, age at first thrombotic event, and association with pregnancy.
  • Congenital deficiency in antithrombin III, protein C, or protein S led to an increased risk of venous thromboembolism.
  • Initial episodes of thrombosis frequently manifested before age 40, with pregnancy identified as a frequent precipitating condition.

Structured PICO

P
Population
78 women with congenital deficiency in antithrombin III (AT III), Protein C (PC), or Protein S (PS)
O
Outcome
Venous thromboembolismhard clinical

Pregnancy is a frequent precipitating condition for early venous thromboembolism in women with congenital deficiencies in AT III, Protein C, or Protein S.

Cite This Study

Conard et al. (1990) studied this question.

synapsesocial.com/papers/6a83c03eaddadcf8413c1df2https://doi.org/10.1055/s-0038-1645218
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of Pregnancy in Women with Antithrombin III Congenital Defect: Report of Four Cases1988 · 52 citations
  2. 2Thrombotic Risk in Hereditary Antithrombin III, Protein C, or Protein S Deficiency1996 · 224 citations
  3. 3Management of Pregnancy with Congenital Antithrombin III Deficiency: Two Case Reports and a Review of the Literature2001 · 30 citations
  4. 4The Risk of Abortion and Stillbirth in Antithrombin-, Protein C-, and Protein S-deficient Women1996 · 222 citations
  5. 5High risk of pregnancy‐related venous thromboembolism in women with multiple thrombophilic defects2007 · 45 citations