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A novel sequential double carbonylation to synthesize anti‐inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one‐pot carbonylative Suzuki and hydroxycarbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cata CX ium ® A catalyst system. Applying optimized conditions different 2‐arylpropionic acids were synthesized in good yields.
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Neumann et al. (2008) studied this question.
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