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New Syntheses of Ibuprofen and Naproxen A new route for the synthesis of α‐arylpropionic acids, in particular for the two most important non‐steroidal antiinflammatory compounds Ibuprofen (5) as well as racemic and optically active Naproxen (12), has been developed. N‐(1‐Arylethyl)formamides 2, 9 are dehydrated to the corresponding isocyanides 3, 10, and these are rearranged by flash pyrolysis to α‐arylpropionitriles 4, 11 which are converted into α‐arylpropionic acids 5, 12 by hydrolysis under standard conditions. The intermediate 1‐(6‐methoxy‐2‐naphthyl)‐ethylamine is resolved via its tartrate or mandelic salts.
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Wolber et al. (1991) studied this question.
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