December 31, 2008European Respiratory JournalOpen Access

Pulmonary infiltrates in patients with malignancies: why and how neutropenia influences clinical reasoning

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Why the study?

Does calcium channel blocker use increase the risk of cancer in patients?

Structured PICO

Does calcium channel blocker use increase the risk of cancer in patients?

Population

865,647 patients from across the UK, comprising three cohorts: CCB exposed (n=150,750), non-CCB matched on age and gender (n=557,931), and unmatched patients unexposed to CCB with at least one other antihypertensive prescription (n=156,966).

Intervention

Calcium channel blockers (CCBs)

Comparator

No exposure to CCBs (matched on age and gender) or exposure to at least one other non-CCB antihypertensive

Outcome

Incidence of cancer (all, breast, prostate, and colon cancers)safety

This large population-based study provides strong evidence that the use of calcium channel blockers is not associated with an increased risk of cancer.

Discussion

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Implication

CCB use was not associated with increased cancer risk; supports observational safety data yet leaves open randomized confirmation.

Cite This Study

Élie Azoulay (2008) studied this question.

synapsesocial.com/papers/6a83c5ba14f94baa955bd802 https://doi.org/10.1183/09031936.00164208

View Full Paper

Ask AI

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Pulmonary infiltrates in patients with malignancies: why and how neutropenia influences clinical reasoning

Structured PICO

Discussion

Implication

Cite This Study

Pulmonary infiltrates in patients with malignancies: why and how neutropenia influences clinical reasoning

Structured PICO

Discussion

Implication

Cite This Study

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