Key result
Antihypertensives show no link to overall breast cancer risk despite higher premenopausal risk.
Why the study?
The causal association between calcium-channel blockers and cancer risk remains uncertain and previous studies have reported conflicting results.
Comparison
Calcium-channel blockers versus β-blockers
Design
Observational study results discussed in a letter format
Authors
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Subgroup signals in premenopausal women and postmenopausal CCB users merit monitoring; leaves open causality and practice implications.
Case-Control (n=3,631)
Yes
Odds Ratio: 1.16 (95% CI 0.94–1.43)
p-value: p=0.17
Hershel Jick (1997) conducted a case-control in Breast cancer (n=3,631). Antihypertensive medications vs. No antihypertensive treatment was evaluated on Overall breast cancer risk (OR 1.16, 95% CI 0.94-1.43, p=0.17). Antihypertensives were not associated with overall breast cancer risk (OR 1.16), but increased risk in premenopausal women (OR 2.15) and postmenopausal calcium-channel blocker users (OR 1.72).
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