This review outlines the neurohumoral and renal mechanisms that lead to edema and decreased renal perfusion in patients with systolic heart failure.
May inform diuretic strategies in systolic HF; leaves open targeted trials on renal perfusion mechanisms.
Preview In patients with congestive heart failure, a diversity of neurohumoral and renal responses are involved in the maintenance of effective circuiting blood volume. The major clinical consequences of these responses are edema formation and, ultimately, decreased renal perfusion. In this article, the authors review the mechanisms that affect renal function in patients with systolic heart failure. A companion article on page 153 discusses use of therapeutic agents that modify these pathophysiologic sequelae.
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Riley et al. (1994) studied this question.
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