Key points are not available for this paper at this time.
Telmisartan may offer renal/vascular benefits over amlodipine in mild CKD hypertension; leaves open whether ARBs outperform CCBs long-term.
Nakamura T, Inoue T, Suzuki T, et al : Comparison of renal and vascular protective effects between telmisartan and amlodipine in hypertensive patients with chronic kidney disease with mild renal insufficiency. Hypertens Res 2008; 31 : 841–850. Article CAS Google Scholar Ludwig M, Stapff M, Ribeiro A, et al : Comparison of the effects of losartan and atenolol on common carotid artery intima-media thickness in patients with hypertension: results of a 2-year, double-blind, randomized, controlled study. Clin Ther 2002; 24 : 1175–1193. Article CAS Google Scholar Tedesco MA, Natale F, Calabrò R : Effects of monotherapy and combination therapy on blood pressure control and target organ damage: a randomized prospective intervention study in a large population of hypertensive patients. J Clin Hypertens ( Greenwich ) 2006; 8 : 634–641. Article CAS Google Scholar Olsen MH, Wachtell K, Neland K, et al : Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudy. Blood Press 2005; 14 : 177–183. Article CAS Google Scholar Sonoda M, Aoyagi T, Takenaka K, Uno K, Nagai R : A one-year study of the antiatherosclerotic effect of the angiotensin-II receptor blocker losartan in hypertensive patients. A comparison with angiotension-converting enzyme inhibitors. Int Heart J 2008; 49 : 95–103. Article CAS Google Scholar Uchiyama-Tanaka Y, Mori Y, Kishimoto N, et al : Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension. Kidney Blood Press Res 2005; 28 : 111–116. Article CAS Google Scholar Ariff B, Zambanini A, Vamadeva S, et al : Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension. Stroke 2006; 37 : 2381–2384. Article CAS Google Scholar Ono H, Minatoguchi S, Watanabe K, et al : Candesartan decreases carotid intima-media thickness by enhancing nitric oxide and decreasing oxidative stress in patients with hypertension. Hypertens Res 2008; 31 : 271–279. Article CAS Google Scholar Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Itoh H : Benefits of candesartan on arterial and renal damage of non-diabetic hypertensive patients treated with calcium channel blockers. Am J Nephrol 2006; 26 : 462–468. Article CAS Google Scholar Tomás JP, Moya JL, Barrios V, et al : Effect of candesartan on coronary flow reserve in patients with systemic hypertension. J Hypertens 2006; 24 : 2109–2114. Article Google Scholar Okura T, Watanabe S, Kurata M, et al : Long-term effects of angiotensin II receptor blockade with valsartan on carotid arterial stiffness and hemodynamic alterations in patients with essential hypertension. Clin Exp Hypertens 2008; 30 : 415–422. Article CAS Google Scholar Kosch M, Levers A, Lang D, et al : A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension. Nephrol Dial Transplant 2008; 23 : 2280–2285. Article CAS Google Scholar Mörtsell D, Malmqvist K, Held C, Kahan T : Irbesartan reduces common carotid artery intima-media thickness in hypertensive patients when compared with atenolol: the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) study. J Intern Med 2007; 261 : 472–479. Article Google Scholar Download references
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Ntaios et al. (2008) studied this question.
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