Why the study?
FABP4 is involved in lipid transport, inflammation, and insulin resistance, prompting investigation into the effects of the specific FABP4 inhibitor BMS309403 on metabolic syndrome and its islet molecular mechanisms.
Does the FABP4 inhibitor BMS309403 improve metabolic syndrome and attenuate islet inflammation and ER stress in leptin receptor knockout rats?
Population
Lepr-/- male rats and their wild littermates
Comparison
Intragastric BMS309403 administration vs control groups
Design
Animal experimental study
Authors
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FABP4 inhibition may benefit islets in animal models; leaves open clinical translation for metabolic syndrome.
Does the FABP4 inhibitor BMS309403 improve metabolic syndrome and attenuate islet inflammation and ER stress in leptin receptor knockout rats?
The FABP4 inhibitor BMS309403 ameliorates islet inflammation and apoptosis in a rat model of metabolic syndrome by suppressing endoplasmic reticulum stress.
Yao et al. (2020) studied this question.
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