Why the study?
Does partial decrease in platelet responsiveness to thrombin via PAR3 knockout protect against thrombosis in mice?
Population
Mouse models (Par3(-/-) and Par4(-/-) mice)
Comparison
Genetic ablation of PAR3 (Par3(-/-)) vs Par4(-/-) mice (and implicitly wild-type mice)
Design
Preclinical
Authors
Loading...
Mouse Par3 knockout confers thrombosis protection comparable to Par4; leaves open selective PAR3 inhibition as antithrombotic strategy in humans.
Does partial decrease in platelet responsiveness to thrombin via PAR3 knockout protect against thrombosis in mice?
Even a partial decrease in mouse platelet responsiveness to thrombin via PAR3 knockout protects against thrombosis, suggesting PAR inhibition as a potential antithrombotic strategy.
Weiss et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: