Population
Authentic double-layered rotavirus subviral particles (DLPs)
Design
Preclinical
Authors
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Offers a tractable in vitro model for rotavirus entry; leaves open in vivo relevance or vaccine applications.
In vitro recoating of rotavirus DLPs with recombinant VP4 and VP7 yields highly infectious particles, providing a model for studying viral assembly and cell entry.
Trask et al. (2006) studied this question.
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