Why the study?
Do antithrombotic agents (ASA, clopidogrel, tirofiban) affect acetylcholine-induced dilation in rat thoracic aorta segments?
Do antithrombotic agents (ASA, clopidogrel, tirofiban) affect acetylcholine-induced dilation in rat thoracic aorta segments?
ASA and clopidogrel may reduce acetylcholine-induced vasodilation in rat thoracic aorta segments at low concentrations.
Should not alter antithrombotic use in patients; hypothesis-generating for endothelial effects in humans.
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Erdem Ali Özkısacık (2012) studied this question.
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