July 1, 1982Journal of Biological ChemistryOpen Access

Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters. Presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production.

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Population

Hamsters with bleomycin-induced pulmonary fibrosis and normal hamsters; human and hamster lung fibroblasts

Comparison

Lung explant conditioned medium from… vs Lung explant CM from normal hamsters, or…

Design

Preclinical

Authors

JCJ G ClarkFred Hutch Cancer Center KKKayla KostalUniversity of British Columbia BMBonaventura MarinoSt. Eugenio Hospital

Discussion

Member takes

Implication

Identifies a potential endogenous brake on fibroblast activation in injured lungs; leaves open its therapeutic translation to human pulmonary fibrosis.

Structured PICO

Population

Hamsters with bleomycin-induced pulmonary fibrosis and normal hamsters; human (IMR-90) and hamster lung fibroblasts

Intervention

Lung explant conditioned medium (CM) from bleomycin-exposed hamsters

Comparator

Lung explant CM from normal hamsters, or untreated fibroblasts

Outcome

Fibroblast proliferation and collagen productionsurrogate

A factor present in fibrotic lungs suppresses fibroblast proliferation and collagen production by increasing PGE2 and cAMP, suggesting a mechanism for limiting collagen accumulation after injury.

Cite This Study

Clark et al. (1982) studied this question.

synapsesocial.com/papers/6a83d34bb5a613d8fb3e98f5 https://doi.org/10.1016/s0021-9258(18)34302-3

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Implication

Identifies a potential endogenous brake on fibroblast activation in injured lungs; leaves open its therapeutic translation to human pulmonary fibrosis.

Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters. Presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters. Presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider