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The rapid expansion of supercritical solutions (RESS) process was applied to produce polymeric microparticles loaded with coenzyme Q 10 (coQ 10 ). Mixtures of poly(lactic acid) (PLA)/(coQ 10 ) and poly(ethylene glycol) (PEG)/(coQ 10 ) containing a cosolvent were dissolved in supercritical CO 2 and sprayed through a nozzle to atmospheric pressure. The effect of process parameters such as encapsulating material/coQ 10 ratio and cosolvent on the properties of the microcapsules were investigated. The characterization of microcapsules was carried out through Scanning Electronic Microscopy (SEM), Infrared Spectrophotometry (IR), Differential Scanning Calorimetry (DSC), and solubility kinetics. More important effect of the ratio encapsulating material/coQ 10, compared with the effect of type of cosolvent, on studied properties was found.
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Vergara-Mendoza et al. (2011) studied this question.
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