Population
A patient with myocardial infarction and their kindred, as well as COS-7 cells for in vitro expression.
Comparison
Thrombomodulin gene mutation (insT 1689) vs Wild type thrombomodulin
Design
Preclinical
Authors
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Supports thrombomodulin mutation role in thrombosis pathogenesis; leaves open human disease relevance.
The identification of a natural thrombomodulin gene mutation causing reduced expression and function supports its potential role in the pathogenesis of occlusive thrombotic disease.
Ireland et al. (2000) studied this question.
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