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December 1, 2002Revue Scientifique et Technique de l OIE

Prospects, including time-frames, for improved foot and mouth disease vaccines

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Why the study?

Does a recombinant adenovirus FMD vaccine protect swine and cattle from FMD clinical signs and viral replication?

Population

Swine and cattle

Design

Review

Authors

MGMarvin J. GrubmanPlum Island Animal Disease CenterPMPeter W. MasonNovartis (United States)

Discussion

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Implication

Promising rapid protection in swine suggests emergency-use potential; leaves open confirmation in cattle and field efficacy.

Structured PICO

Does a recombinant adenovirus FMD vaccine protect swine and cattle from FMD clinical signs and viral replication?

P
Population
Swine and cattle
I
Intervention
Replication-defective recombinant human adenovirus containing the capsid and 3C proteinase coding regions of FMD virus (FMDV)
O
Outcome
Protection from clinical signs of FMD and FMDV replication upon challenge with virulent animal-passaged homologous virussurrogate

A novel recombinant adenovirus-based FMD vaccine shows promise in protecting swine and cattle from clinical disease and viral replication.

Cite This Study

Grubman et al. (2002) studied this question.

synapsesocial.com/papers/6a83d4ea5894adb48d4a1074https://doi.org/10.20506/rst.21.3.1360
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