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August 1, 1991Molecular and Cellular BiologyOpen Access

The Immunosuppressant FK-506 Specifically Inhibits Mitogen- Induced Activation of the Interleukin-2 Promoter and the Isolated Enhancer Elements NFIL-2A and NF-AT1

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Authors

SBSunandita S. BanerjiNorthwestern University JPJaney N. ParsonsMerck & Co., Inc., Rahway, NJ, USA (United States)MTMichael J. TocciMemorial Medical Center

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Implication

Both drugs block NF-AT1/NFIL-2A transcription without disrupting factor binding; leaves open the trans-acting target in primary human T cells.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Banerji et al. (1991) studied this question.

synapsesocial.com/papers/6a83db404d653d38678de19b https://doi.org/10.1128/mcb.11.8.4074-4087.1991

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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

1Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression1989 · 324 citations
2T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression1987 · 529 citations