A novel portable platform based on electric potential sensing technology successfully detects non-invasive in vivo electrocardiogram activity in embryonic zebrafish.
Provides initial feasibility in zebrafish embryos; leaves open translation to mammalian models or clinical use.
In this letter, we report the continuous detection of the cardiac electrical activity in embryonic zebrafish using a non-invasive approach. We present a portable and cost-effective platform based on the electric potential sensing technology, to monitor in vivo electrocardiogram activity from the zebrafish heart. This proof of principle demonstration shows how electrocardiogram measurements from the embryonic zebrafish may become accessible by using electric field detection. We present preliminary results using the prototype, which enables the acquisition of electrophysiological signals from in vivo 3 and 5 days-post-fertilization zebrafish embryos. The recorded waveforms show electrocardiogram traces including detailed features such as QRS complex, P and T waves.
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Rendón-Morales et al. (2015) studied this question.
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