Why the study?
Myocardial fibrosis in aortic stenosis precedes left ventricular decompensation and portends an adverse prognosis, prompting investigation into whether early valve intervention reduces all-cause death or unplanned aortic stenosis-related hospitalization.
Does early valve intervention reduce all-cause death or unplanned aortic stenosis-related hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis?
Population
224 asymptomatic patients with severe aortic stenosis and myocardial fibrosis
Comparison
Early valve intervention with TAVR or SAVR vs guideline-directed conservative management
Design
Prospective, randomized, open-label, masked end point trial at 24 cardiac centers
Authors
Loading...
Early intervention did not reduce the primary composite in asymptomatic severe AS with fibrosis; leaves open fibrosis-guided timing in larger trials.
Does early valve intervention reduce all-cause death or unplanned aortic stenosis-related hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis?
Early aortic valve intervention in asymptomatic severe aortic stenosis with myocardial fibrosis did not significantly reduce the composite of all-cause death or AS-related hospitalization, though the trial was underpowered.
Loganath et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: