What question did this study set out to answer?

To determine the familial inheritance patterns of polycystic ovarian disease, hirsuties, and oligomenorrhoea, and examine their possible genetic relationship to premature male balding.

September 1, 1979Clinical Endocrinology

The Inheritance of Polycystic Ovarian Disease and a Possible Relationship to Premature Balding

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To determine the familial inheritance patterns of polycystic ovarian disease, hirsuties, and oligomenorrhoea, and examine their possible genetic relationship to premature male balding.
Assessed family histories of hirsuties, oligomenorrhoea, and infertility among first-degree female relatives, and premature balding among first-degree male relatives of 284 hirsute patients (n=136 assessed for male relatives) versus controls.
Evaluated histories of oligomenorrhoea and infertility among first-degree relatives of 90 non-hirsute patients with oligomenorrhoea, divided into those with gynaecographically enlarged ovaries (n=45) and normal-sized ovaries (n=45), compared to controls.
First-degree female relatives of hirsute patients had a significantly higher prevalence of hirsuties (P < 0.001), and first-degree male relatives had a significantly higher prevalence of premature balding (P < 0.001) compared with controls, consistent with modified dominant inheritance.
First-degree relatives of non-hirsute patients with enlarged ovaries demonstrated a significantly higher prevalence of oligomenorrhoea and infertility than controls (P < 0.001), whereas those with normal-sized ovaries showed an increase that did not reach statistical significance (P = 0.06).
Relatives of non-hirsute patients showed no increase in hirsuties or premature balding compared to controls, indicating that hirsute and non-hirsute polycystic ovarian presentations represent aetiologically distinct disorders.

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Implication

Case-control family study demonstrates increased hirsuties and premature balding among relatives of polycystic ovarian disease patients, suggesting modified dominant inheritance.

Cite This Study

Ferriman et al. (1979) studied this question.

synapsesocial.com/papers/6a83df3b3a3643f3cd3e9fa6 https://doi.org/10.1111/j.1365-2265.1979.tb03077.x

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Implication

Case-control family study demonstrates increased hirsuties and premature balding among relatives of polycystic ovarian disease patients, suggesting modified dominant inheritance.

The Inheritance of Polycystic Ovarian Disease and a Possible Relationship to Premature Balding

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Discussion

Implication

Cite This Study

The Inheritance of Polycystic Ovarian Disease and a Possible Relationship to Premature Balding

Key Points

Discussion

Implication

Cite This Study

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