Key result
Hirsutism in PCOS is linked to ~5 mg/dl higher fasting glucose and elevated triglycerides.
Why the study?
Polycystic ovary syndrome presents with varied phenotypes including hirsutism, and differences in clinical, biochemical, and hormone profiles between hirsute and non-hirsute PCOS females are not well characterized.
What are the differences in clinical, biochemical, and hormone profiles between hirsute and non-hirsute patients with PCOS?
Cross-Sectional (n=105)
No
What are the differences in clinical, biochemical, and hormone profiles between hirsute and non-hirsute patients with PCOS?
Absolute Event Rate: 91% vs 85.6%
p-value: p=0.02
Hirsute PCOS patients exhibit worse metabolic profiles, specifically higher fasting blood glucose and triglycerides, compared to non-hirsute PCOS patients.
Background: Polycystic ovary syndrome (PCOS), a common endocrinopathy present with variety of phenotypes with broad spectrum of clinical symptoms. Hyperandrogenism characterized with the presence of hirsutism remains an important feature of PCOS. Aim: The present study was conducted to assess difference in the clinical, biochemical and hormone profile in hirsute and non-hirsute females with PCOS. Methods: Detailed physical and clinical history was taken in all subjects. Hormonal and biochemical assays were performed by ECLIA. Results: 105 normoglycemic cases were enrolled for this study. The mean age of patients was 22.19 ±4.4 years and the mean age of menarche was 13.3±1.4 years. Acne was present in more than 50% of our cases. 81% cases were hirsute and only 19% were non- hirsute. Mean fasting blood glucose and triglycerides were found to be statistically significant between the two groups. A positive trend of hirsutism was found to be associated with irregular cycles and family history of type-2 diabetes mellitus (T2DM). Conclusion: The mean blood glucose and triglycerides was elevated in hirsute PCOS, while as BMI, weight and waist circumference was slightly elevated in non-hirsute PCOS females.
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Amaladasu Prasanthi (2020) conducted a cross-sectional in Polycystic ovary syndrome (n=105). Hirsutism vs. Non-hirsute phenotype was evaluated on Fasting blood glucose (mg/dl) (p=0.02). Hirsute women with PCOS had significantly higher mean fasting blood glucose (91 vs 85.6 mg/dl) and triglycerides (167.4 vs 124.9 mg/dl) compared to non-hirsute women with PCOS.
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