Bilateral carotid occlusion in anesthetized dogs increases arterial and venous oxygen content and hematocrit via splenic contraction, without significantly altering cardiac output.
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Splenic contraction may boost oxygen content without changing cardiac output in dogs; leaves open relevance to human compensatory mechanisms.
Changes in cardiac output, mean arterial blood pressure, hematocrit ratio, and arterial and venous oxygen content resulting from bilateral carotid occlusion were investigated. Cardiac output exhibited no significant alteration during endosinusal hypotension, and the systemic hypertension engendered was attributed to an increase in vasomotor tone. Arterial and venous oxygen content, as well as hematocrit ratio, increased significantly during the period of carotid occlusion. This increase was ascribed to splenic contraction evoked by carotid occlusion, since no comparable augmentation was observed when the splenic circulation was temporarily interrupted.
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Brind et al. (1956) studied this question.
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