Population
Cultured cerebellar granule cells
Comparison
Transfection with cDNA encoding a… vs Untransfected or baseline developing cells
Design
Preclinical
Authors
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No immediate clinical implications for cerebellar disorders; leaves open Kv4.2 targeting in human neuronal maturation.
Kv4 subfamily channels mediate A-type K+ currents in developing cerebellar granule cells, which is critical for suppressing excitability during maturation.
Shibata et al. (2000) studied this question.
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