February 15, 2008The Journal of PhysiologyOpen Access

Ternary Kv4.2 channels recapitulate voltage‐dependent inactivation kinetics of A‐type K⁺ channels in cerebellar granule neurons

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Population

Heterologous mammalian cells and native cerebellar granule neurons

Comparison

Expression of Kv4.2 channel complexes vs Comparison among different Kv4.2 channel…

Design

Preclinical

Authors

YAYimy AmarilloConsejo Nacional de Investigaciones Científicas y Técnicas JSJosé A. De Santiago‐CastilloThomas Jefferson University KDKevin DoughertyMichigan State University

Discussion

Member takes

Implication

Supports closed-state inactivation model for native neuronal Kv4 channels; leaves open cardiac Ito relevance and clinical translation.

Structured PICO

Population

Heterologous mammalian cells and native cerebellar granule neurons

Intervention

Expression of Kv4.2 channel complexes (Kv4.2 alone, with KChIP1, with DPPX-S, or with both)

Comparator

Comparison among different Kv4.2 channel compositions and native neuronal currents

Outcome

Voltage dependence of the inactivation rate of the channelssurrogate

Native somatically recorded Kv4 channels in neurons likely include both KChIP and DPPL accessory proteins, with their activity regulated by preferential closed-state inactivation.

Cite This Study

Amarillo et al. (2008) studied this question.

synapsesocial.com/papers/69d5706c75589c71d767db8b https://doi.org/10.1113/jphysiol.2007.150540

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Ternary Kv4.2 channels recapitulate voltage‐dependent inactivation kinetics of A‐type K⁺ channels in cerebellar granule neurons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ternary Kv4.2 channels recapitulate voltage‐dependent inactivation kinetics of A‐type K⁺ channels in cerebellar granule neurons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider