Why the study?
Does enalapril or rosuvastatin improve vascular and neural dysfunction in obese Zucker rats?
Population
Obese Zucker rats at 20 weeks of age (animal model for metabolic syndrome)
Comparison
Enalapril or rosuvastatin for 12 weeks vs Lean rats and presumably untreated obese Zucker…
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change practice; hypothesis-generating for neuroprotection in metabolic syndrome models.
Does enalapril or rosuvastatin improve vascular and neural dysfunction in obese Zucker rats?
Enalapril and rosuvastatin attenuate vascular and neural dysfunction in a rat model of metabolic syndrome, suggesting potential neuroprotective effects independent of glycemic control.
Oltman et al. (2008) studied this question.
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