Why the study?
Does exposure to anisosmolar solutions affect Na(+)-K+ pump activity in mammalian cardiac myocytes?
Population
Mammalian cardiac myocytes (single ventricular myocytes and intact papillary muscles)
Comparison
Exposure to anisosmolar solutions vs Isosmolar solution (310 mosM)
Design
Preclinical
Authors
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Cell volume may modulate myocyte Na-K pump activity; extends basic observations but leaves open clinical relevance.
Does exposure to anisosmolar solutions affect Na(+)-K+ pump activity in mammalian cardiac myocytes?
Osmotic myocyte swelling stimulates the sarcolemmal Na(+)-K+ pump by increasing its apparent affinity for Na+, whereas shrinkage inhibits the pump.
Whalley et al. (1993) studied this question.
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