Population
Xenopus oocytes and Sf9 cells expressing human or rat isoforms of the skeletal muscle chloride channel
Comparison
Exposure to various foreign anions vs Chloride (Cl-)
Design
Preclinical
Authors
Loading...
Distinguishes regulatory from selectivity sites in rClC-1; leaves open conservation and druggability in human channelopathies.
The study demonstrates that in the ClC-1 chloride channel, the regulatory binding site that opens the channel is distinct from the selectivity center and is located closer to the external side.
Rychkov et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: