August 1, 1976British Journal of Haematology

Acquired von Willebrand Syndrome with Inhibitors Both to Factor VIII Clotting Activity and Ristocetin‐Induced Platelet Aggregation

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Population

1 patient with acquired von Willebrand's syndrome and 13 other patients with antibodies to FVIIIC but no…

Design

Case_report

Authors

PSP StableforthSandwell General Hospital GTGabriele TamagniniVilla Torri Hospital KDKatharine M. DormandyThe Royal Free Hospital

Discussion

Member takes

Implication

May indicate anti-FVIIIRAg etiology in acquired VWD; hypothesis-generating and requires validation before diagnostic adoption.

Structured PICO

Population

1 patient with acquired von Willebrand's syndrome and 13 other patients with antibodies to FVIIIC but no evidence of acquired vWs

Outcome

Demonstration of antibodies directed against FVIIIRAgsurrogate

This case report demonstrates that acquired von Willebrand's syndrome can be caused by antibodies directed against factor VIII-related antigen, detectable via platelet eluate inhibition of Ristocetin-induced aggregation.

Cite This Study

Stableforth et al. (1976) studied this question.

synapsesocial.com/papers/6a83e340be3ac444ce3ea2d0 https://doi.org/10.1111/j.1365-2141.1976.tb03575.x

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Acquired von Willebrand Syndrome with Inhibitors Both to Factor VIII Clotting Activity and Ristocetin‐Induced Platelet Aggregation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acquired von Willebrand Syndrome with Inhibitors Both to Factor VIII Clotting Activity and Ristocetin‐Induced Platelet Aggregation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider