Why the study?
Does furosemide improve renal hemodynamics and alter angiogenesis gene expression in a rat model of acute renal ischemia/reperfusion?
Population
24 male Sprague-Dawley rats with an acute renal failure model
Comparison
Furosemide infusion at 30 microg/kg/hr vs Saline infusion
Design
Preclinical
Follow-up
6 hours
Authors
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Furosemide effects in rat renal IRI remain preclinical; hypothesis-generating and should not alter AKI management.
Does furosemide improve renal hemodynamics and alter angiogenesis gene expression in a rat model of acute renal ischemia/reperfusion?
In a rat model of acute renal ischemia/reperfusion, furosemide infusion improved renal hemodynamics and attenuated ischemia-related changes in angiogenesis gene expression.
Aravindan et al. (2006) studied this question.
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