Why the study?
Do different fluoroquinolone antibacterial agents have varying effects on action potential duration in guinea pig ventricular myocardia?
Do different fluoroquinolone antibacterial agents have varying effects on action potential duration in guinea pig ventricular myocardia?
Fluoroquinolones exhibit varying degrees of action potential duration prolongation in preclinical models, suggesting differential risks for QT interval prolongation.
Sparfloxacin may confer greater QT risk than other fluoroquinolones; hypothesis-generating and requires human validation before clinical implications.
We examined the effects of ten fluoroquinolone antibacterial agents, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin, tosufloxacin, gatifloxacin, grepafloxacin, moxifloxacin and sparfloxacin, on action potentials recorded from guinea pig ventricular myocardia. Sparfloxacin prolonged action potential duration (APD) by about 8% at 10 microM and 41% at 100 microM. Gatifloxacin, grepafloxacin and moxifloxacin also prolonged APD at 100 microM by about 13%, 24% and 25%, respectively. In contrast, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin and tosufloxacin had little or no APD-prolonging effect at concentrations as high as 100 microM. These findings suggest that there are differences in potency to prolong QT interval among the fluoroquinolones.
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Hagiwara et al. (2001) studied this question.
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