What question did this study set out to answer?

To evaluate counterregulatory cortisol and growth hormone secretion during spontaneous hypoglycemia and evaluate adrenal response to ACTH stimulation in neonates with hyperinsulinemic hypoglycemia.

May 12, 2021Acta bio-medica : Atenei ParmensisOpen Access

Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH).

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Authors

SAShayma AhmedHamad General Hospital ASAshraf SolimanHamad General Hospital VSVincenzo De SanctisChild, Adolescent and Family Mental Health

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Implication

Clinical study reveals impaired cortisol secretion during hypoglycemia despite normal ACTH response in neonates with hyperinsulinemia, highlighting potential hypothalamic-pituitary dysfunction.

Key Points

To evaluate counterregulatory cortisol and growth hormone secretion during spontaneous hypoglycemia and evaluate adrenal response to ACTH stimulation in neonates with hyperinsulinemic hypoglycemia.
Evaluated 9 neonates (N=9) diagnosed with hyperinsulinemic hypoglycemia during the first 2 weeks of life.
Measured plasma glucose, beta-hydroxybutyrate, insulin, ACTH, cortisol, and growth hormone levels during episodes of spontaneous hypoglycemia.
Conducted a standard-dose intravenous ACTH stimulation test to assess peak cortisol response.
During spontaneous hypoglycemia (mean glucose 1.42 ± 0.7 mmol/L), infants showed blunted cortisol (94.7 ± 83.1 nmol/L) and low ACTH (mean 39.4 ± 20 pg/mL), whereas growth hormone appropriately increased (>20 mIU/L in all infants, mean 82.4 ± 29 mIU/L).
All infants achieved a normal peak cortisol response (>500 nmol/L) following exogenous intravenous ACTH stimulation, despite basal cortisol failing to rise during hypoglycemia.

Cite This Study

Ahmed et al. (2021) studied this question.

synapsesocial.com/papers/6a83ec8fab0020f36262daa6 https://doi.org/10.23750/abm.v92i2.11396

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Implication

Clinical study reveals impaired cortisol secretion during hypoglycemia despite normal ACTH response in neonates with hyperinsulinemia, highlighting potential hypothalamic-pituitary dysfunction.

Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH).

Discussion

Member takes

Implication

Key Points

Cite This Study

Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH).

Discussion

Member takes

Implication

Key Points

Cite This Study

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