Gastric acid secretion was stimulated by insulin hypoglycemia in Pavlov pouch dogs with isolated pouches of the duodenal bulb. Perfusion of the duodenal bulb with 0.1 N HCI abolished the secretory response to a low dose of insulin (0.2 I.U. per kg b.w.), whereas the responses to higher doses (0.4 and 0.8 I.U. per kg b.w.) were only partially inhibited. It is suggested that the bulbar mechanism inhibits secretory responses to insulin hypoglycemia by interference with the stimulatory action of gastrin.
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Göran Nilsson (1969) studied this question.
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