January 1, 2001Drug Development Research

Study of aggregation of platelets lacking the P2Y1 receptor

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Population

Mice deficient for the P2Y1 receptor and isolated platelets

Design

Review

Authors

JFJ FabreInserm BKBrian F. KingBristol-Myers Squibb (United States)BKBeverly H. KollerUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Suggests redundant ADP signaling in platelets; leaves open validation of additional receptors as antithrombotic targets.

Structured PICO

Population

Mice deficient for the P2Y1 receptor and isolated platelets

Intervention

ADP exposure

Outcome

ADP-induced platelet aggregationsurrogate

This review highlights that additional ADP receptors beyond P2Y1 are involved in platelet aggregation, laying the mechanistic groundwork for understanding purinergic signaling in thrombosis.

Cite This Study

Fabre et al. (2001) studied this question.

synapsesocial.com/papers/6a83ef2720cfb2932ffe2afd https://doi.org/10.1002/ddr.1109

View Full Paper

Ask AI

Bookmark

Study of aggregation of platelets lacking the P2Y1 receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Study of aggregation of platelets lacking the P2Y1 receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider