What question did this study set out to answer?

To determine whether the arterial hypertension induced by desoxycorticosterone acetate stems primarily from sodium and fluid retention or from distinct hormonal mechanisms.

August 12, 1944JAMA

Effect of Desoxycorticosterone Acetate on the Blood Pressure of Man

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Authors

GPGeorge A. PereraUniversidade Federal de São Paulo

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Implication

Clinical investigation evaluates blood pressure and fluid dynamics under desoxycorticosterone acetate in humans, suggesting mineralocorticoid-induced hypertensive mechanisms.

Key Points

To determine whether the arterial hypertension induced by desoxycorticosterone acetate stems primarily from sodium and fluid retention or from distinct hormonal mechanisms.
Investigated the physiological effects of desoxycorticosterone acetate and sodium chloride administration in human subjects.
Evaluated changes across arterial blood pressure, blood volume, and sodium concentration.
Clinical observations confirm sustained administration of desoxycorticosterone esters raises arterial blood pressure above normal physiological levels in humans.
Animal models consistently exhibit significant blood pressure elevations and vascular lesion formation following continuous exposure to desoxycorticosterone.

Cite This Study

George A. Perera (1944) studied this question.

synapsesocial.com/papers/6a83f1d8288d0a58643c1b06 https://doi.org/10.1001/jama.1944.02850330028007

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Implication

Clinical investigation evaluates blood pressure and fluid dynamics under desoxycorticosterone acetate in humans, suggesting mineralocorticoid-induced hypertensive mechanisms.

Effect of Desoxycorticosterone Acetate on the Blood Pressure of Man

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Desoxycorticosterone Acetate on the Blood Pressure of Man

Discussion

Member takes

Implication

Key Points

Cite This Study

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