Key result
Experimental hypertension models exhibit adrenergic abnormalities including alpha and beta postsynaptic receptor imbalance.
Why the study?
Elevated circulating catecholamine levels and altered sympathoadrenal reactivity suggest multiple abnormalities in adrenergic mechanisms in experimental and human hypertension.
Population
DOCA-salt hypertensive rats, spontaneously hypertensive rats, and human hypertension models
Comparison
Alterations in pre- and post-synaptic adrenergic mechanisms
Design
Review of experimental and clinical studies
Authors
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Adrenergic imbalances may contribute to hypertension pathogenesis; leaves open whether targeting them improves human outcomes.
This review highlights the role of altered sympathoadrenal reactivity and adrenergic receptor imbalances in the pathogenesis of experimental and human hypertension.
Champlain et al. (1989) conducted a review in Hypertension. Deoxycorticosterone acetate (DOCA)-salt and spontaneous hypertension was evaluated. Experimental models of hypertension exhibit multiple abnormalities in pre- and post-synaptic adrenergic mechanisms, including an imbalance between alpha- and beta-postsynaptic receptors.
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