Key result
This review highlights contradictory data regarding the role of the sympathetic nervous system, endothelin, and vasopressin in deoxycorticosterone acetate (DOCA)-salt hypertension in rats.
Population
Rats with deoxycorticosterone acetate (DOCA)-salt hypertension
Design
Review
Authors
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Contradictory data on neural mechanisms in DOCA-salt hypertension leaves open drivers of hypervolaemic hypertension; targeted studies required.
Understanding the neurohumoral mechanisms in DOCA-salt hypertensive rats may provide insights into human hypertension driven by hypervolaemia, hyperaldosteronism, and high salt intake.
Yemane et al. (2009) conducted a review in Deoxycorticosterone acetate (DOCA)-salt hypertension. Neural and non-neural mechanisms (sympathetic nervous system, endothelin, vasopressin) was evaluated. This review highlights contradictory data regarding the role of the sympathetic nervous system, endothelin, and vasopressin in deoxycorticosterone acetate (DOCA)-salt hypertension in rats.
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