Population
Sinoaortic-denervated and sham-operated rats
Comparison
Deoxycorticosterone acetate (DOCA)-salt loading vs Control rats (sham-operated or non-DOCA-loaded)
Design
Preclinical
Follow-up
21 days
Authors
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Impaired central baroreflex precedes hypertension in this model; leaves open its causal contribution to salt-sensitive hypertension.
The central component of the baroreceptor reflex mediated by the aortic depressor nerve is impaired before hypertension develops in DOCA-salt-treated rats, potentially contributing to the development of hypertension.
Nakamura et al. (1988) studied this question.
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