A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM
Population
Yeast and mammalian cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open FHL proteins as targets for CREB/CREM research in cardiovascular models.
Structured PICO
P
Population
Yeast and mammalian cells
I
Intervention
Coexpression of four-and-a-half-LIM-domain (FHL) proteins with CREB and CREM
O
Outcome
Transcriptional activationsurrogate
Identifies a family of tissue-specific LIM-only coactivators (FHL proteins) that selectively activate CREB and CREM transcription factors independently of CBP.
Cite This Study
Fimia et al. (2000) studied this question.