Why the study?
Does experimental heart failure induced by left ventricular myocardial infarction depress right ventricular contractile protein function in rats?
Population
Rats with experimental heart failure induced by left ventricular myocardial infarction and sham-operated rats
Comparison
Experimental heart failure induced by left… vs Sham-operated rats
Design
Preclinical
Follow-up
24 weeks post-MI
Authors
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RV myofilament dysfunction contributes to reduced force in post-MI HF models; hypothesis-generating, leaves open human translation.
Does experimental heart failure induced by left ventricular myocardial infarction depress right ventricular contractile protein function in rats?
In a rat model of heart failure post-LV myocardial infarction, reduced right ventricular force development is partly due to depressed function of contractile filaments.
Tombe et al. (1996) studied this question.
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