What question did this study set out to answer?

To examine the relationship between proteinuria and all-cause and cause-specific mortality in individuals with Type 1 and Type 2 diabetes.

February 1, 1995Diabetic Medicine

Proteinuria and Mortality in Diabetes: the WHO Multinational Study of Vascular Disease in Diabetes

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Why the study?

Does proteinuria increase the risk of mortality in patients with Type 1 and Type 2 diabetes?

Population

4,422 patients, aged 35-55 at baseline, from the WHO Multinational Study of Vascular Disease in Diabetes.

Comparison

Light or heavy proteinuria (exposure) vs No proteinuria

Design

Cohort

Follow-up

mean 9.4 +/- 3.1 years

Authors

JSJudith StephensonLondon Women's Clinic SKS. KennyCenters for Disease Control and Prevention LSL. K. StevensSemmelweis University

Discussion

Member takes

Implication

Proteinuria marks higher mortality risk in type 1 and 2 diabetes; extends prior observational associations but leaves causal effects open.

Key Points

To examine the relationship between proteinuria and all-cause and cause-specific mortality in individuals with Type 1 and Type 2 diabetes.
Evaluated 1,188 patients with Type 1 diabetes and 3,234 patients with Type 2 diabetes aged 35–55 at baseline in the WHO Multinational Study of Vascular Disease in Diabetes.
Followed participants prospectively for a mean of 9.4 ± 3.1 years to assess the effect of light and heavy proteinuria on mortality, adjusting for age, diabetes duration, blood pressure, cholesterol, and smoking.
In Type 1 diabetes, adjusted all-cause mortality ratios were 1.5 (95% CI, 1.1–2.0) for light proteinuria and 2.9 (95% CI, 2.2–3.8) for heavy proteinuria compared with no proteinuria.
In Type 2 diabetes, adjusted all-cause mortality ratios were 1.5 (95% CI, 1.2–1.8) for light proteinuria and 2.8 (95% CI, 2.3–3.4) for heavy proteinuria.
Proteinuria was associated with significantly increased mortality across all causes, showing the strongest relationship with renal failure deaths followed by cardiovascular deaths.

Structured PICO

Does proteinuria increase the risk of mortality in patients with Type 1 and Type 2 diabetes?

Population

4,422 patients (1,188 with Type 1 diabetes and 3,234 with Type 2 diabetes), aged 35-55 at baseline, from the WHO Multinational Study of Vascular Disease in Diabetes.

Intervention

Light or heavy proteinuria (exposure)

Comparator

No proteinuria

Outcome

All-cause mortalityhard clinical

Proteinuria is a significant and non-specific risk factor for increased all-cause, cardiovascular, and renal mortality in both Type 1 and Type 2 diabetes.

Cite This Study

Stephenson et al. (1995) studied this question.

synapsesocial.com/papers/6a83f66ba3cef8348e997bf1 https://doi.org/10.1111/j.1464-5491.1995.tb00446.x

Topics

Hypertension management

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Implication

Proteinuria marks higher mortality risk in type 1 and 2 diabetes; extends prior observational associations but leaves causal effects open.

Proteinuria and Mortality in Diabetes: the WHO Multinational Study of Vascular Disease in Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Proteinuria and Mortality in Diabetes: the WHO Multinational Study of Vascular Disease in Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider