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Experimental study reveals that cooling enhances myoendothelial coupling in cutaneous arteries, suggesting impaired signaling may cause excessive vasoconstriction and tissue injury.
Cold causes cutaneous vasoconstriction to restrict heat loss. Although cold also initiates cutaneous dilatation, the mechanisms and role of this dilatation have not been clearly defined. This study demonstrates that cooling increases myoendothelial coupling between smooth muscle and endothelial cells in cutaneous arteries, which is associated with increased endothelium-derived hyperpolarization (EDH)-type dilatation. Dysfunction in this process may contribute to excessive cold-induced constriction and tissue injury.
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Flavahan et al. (2020) studied this question.
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