Why the study?
Does oral administration of prostaglandins E2 and F2α stimulate uterine contractions in humans?
Does oral administration of prostaglandins E2 and F2α stimulate uterine contractions in humans?
Oral prostaglandins E2 and F2α can stimulate uterine contractions, suggesting potential clinical use as oral abortifacients and oxytocics, though higher doses cause gastrointestinal side effects.
May inform early exploration of oral prostaglandins in obstetrics; leaves open dosing, efficacy, and tolerability in controlled trials.
Summary The effects of oral administration of prostaglandins E 2 and F 2α have been studied in 42 male and non‐pregnant female volunteers and in pregnant women. Oral doses of 0.5 mg. prostaglandin E 2 or 5 mg. prostaglandin F 2α stimulated the pregnant uterus in vivo at term to contract. Single oral doses of up to 3 mg. of prostaglandin E 2 or 30 mg. prostaglandin F 2α did not produce any noticeable effect on the gastrointestinal tract or the cardiovascular system. Doses of 4.5 mg. prostaglandin E 2 and 40.50 mg. prostaglandin F 2α produced contractions of the uterus in early pregnancy and in addition produced diarrhoea and vomiting. The implications of these findings with respect to the clinical use of prostaglandins as oral abortifacients and oxytocics are discussed.
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S.M.M. Karim (1971) studied this question.
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