Population
Isolated segments of rat tail artery and aorta
Comparison
NG-nitro-L-arginine methylester (L-NAME) 30 microM vs Control (absence of L-NAME)
Design
Preclinical
Authors
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Should not alter clinical alpha-1 modulation; leaves open receptor reserve as key modulator across vascular beds.
The modulation of alpha 1-adrenoceptor-mediated contraction by L-NAME differs between rat aorta and tail artery due to differences in receptor reserve, independent of phosphoinositide turnover.
Tabernero et al. (1996) studied this question.
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