What question did this study set out to answer?

To determine whether cyclic guanosine monophosphate inhibits vascular smooth muscle contraction by preventing phosphatidylinositol hydrolysis.

March 1, 1986Circulation ResearchOpen Access

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

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Authors

RRRobert M. RapoportUniversity of Cincinnati Medical Center

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Implication

Experimental study demonstrates that cyclic GMP inhibits vascular contraction by suppressing phosphatidylinositol hydrolysis in rat aorta, suggesting a shared smooth muscle relaxation pathway.

Key Points

To determine whether cyclic guanosine monophosphate inhibits vascular smooth muscle contraction by preventing phosphatidylinositol hydrolysis.
Measured norepinephrine-induced contractile responses and inositol monophosphate accumulation, an index of phosphatidylinositol hydrolysis, in isolated rat aorta preparations.
Treated vascular tissues with the soluble guanylate cyclase activator sodium nitroprusside, particulate guanylate cyclase activator atriopeptin II, acetylcholine (with and without intact endothelium), or the cell-permeable cyclic nucleotide analogue 8-bromo cyclic guanosine monophosphate.
Sodium nitroprusside and atriopeptin II both inhibited norepinephrine-induced aortic contraction and suppressed accumulation of inositol monophosphate.
Acetylcholine exerted inhibitory effects on contraction and inositol monophosphate accumulation exclusively in the presence of intact endothelium.
Direct application of 8-bromo cyclic guanosine monophosphate inhibited both contraction and inositol monophosphate accumulation, confirming the inhibitory mechanism occurs downstream regardless of how cyclic GMP levels rise.

Cite This Study

Robert M. Rapoport (1986) studied this question.

synapsesocial.com/papers/6a829776c26e934cd221da27 https://doi.org/10.1161/01.res.58.3.407

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Implication

Experimental study demonstrates that cyclic GMP inhibits vascular contraction by suppressing phosphatidylinositol hydrolysis in rat aorta, suggesting a shared smooth muscle relaxation pathway.

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

Discussion

Member takes

Implication

Key Points

Cite This Study

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

Discussion

Member takes

Implication

Key Points

Cite This Study

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